Table of Contents

• Mid-life: a critical window for intervention during aging

  Evandro Lopes de Carvalho

  Mid-life represents a pivotal period marked by profound physiological and metabolic transitions, increasing susceptibility to chronic diseases. This review explores the molecular and systemic underpinnings of mid-life transition by integrating insights from recent studies that elucidate aging-associated changes in the plasma proteome, immune system, adipose tissue remodeling, and cellular senescen...

  REVIEW | Published: 14 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 2

  Pages: 1-8   PDF(1340KB)   Views：1176Downloads：14

• The role of cardiovascular aging in heart failure

  Denise Greco, Kofi Oti Boakye-Yiadom

  Cardiovascular aging represents a critical factor contributing to the rising prevalence of heart failure in aging populations, as structural and functional changes occurring in the heart and vasculature during aging result in an increased susceptibility to heart failure. Different aging-related molecular mechanisms contribute to these cardiovascular changes. Among these molecular mechanisms are ep...

  REVIEW | Published: 29 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 2

  Pages: 9-18   PDF(1450KB)   Views：918Downloads：16

• RETRACTED: Molecular bases of adipose tissue aging

  Aakeel Ahmad, Manlio Fusciello

  No abstract....

  RETRACTED ARTICLE | Published: 07 Apr 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 2

  Pages: 19-27   PDF(1740KB)   Views：774Downloads：29

• The role of adipose tissue aging in organismal aging

  Al Maskari Raya, Nomier Yousra

  Aging, a complex process marked by the progressive decline in cellular and systemic functions, increases vulnerability to metabolic and age-associated disorders. Adipose tissue, being the largest energy reservoir in the body, plays a crucial role in regulating metabolism and maintaining energy balance. Adipose tissue exhibit early onset of age-associated dysfunctions, which ultimately contribute t...

  REVIEW | Published: 23 Feb 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 2

  Pages: 28-37   PDF(2470KB)   Views：967Downloads：5

• Aging-related comorbidities, life-style interventions and therapeutic strategies in heart failure

  Nam Nhut Phan, Fakhar-un-Nisa Yunus

  Aging is a key risk factor for heart failure which significantly contributes to progressive structural and functional deteriorations in the heart, such as increased incidence of left ventricular hypertrophy, decline in left ventricle diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac amyloidosis, all contributing to compromised cardiac performance and le...

  REVIEW | Published: 30 Mar 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 2

  Pages: 38-47   PDF(1670KB)   Views：695Downloads：3

• Relationship between leptin receptor and TNF-α in obesity and polycystic ovary syndrome

  Omnia Mohamed Attia, Ahmed Attia Ahmed Abdelmoaty

  The pathophysiology of polycystic ovarian syndrome (PCOS), a prevalent endocrine disorder, is intimately associated with obesity, particularly the abdominal phenotype. This accumulation of visceral fat is one of the primary causes of insulin resistance and the resulting metabolic dysregulation. Two key mediators in this process are leptin and TNF-α. The adipokine leptin regulates energy balance an...

  REVIEW | Published: 25 Aug 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 2

  Pages: 48-57   PDF(1040KB)   Views：42Downloads：1