Table of Contents

• Molecular bases of adipose tissue aging

  Aakeel Ahmad, Manlio Fusciello

  Aging impacts each and every living organism. In higher organisms, it is an asynchronous process with its onset and pace varying among tissue types as well as among different cell types within a tissue. Adipose tissue is the largest energy depot in the body and is an endocrine organ responsible for metabolic homeostasis. Adipose tissue aging is marked by fat redistribution, with increased visceral...

  REVIEW | Published: 14 Feb 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 19-27   PDF(1740KB)   Views：41Downloads：2

• The role of cardiovascular aging in heart failure

  Denise Greco, Kofi Oti Boakye-Yiadom

  Cardiovascular aging represents a critical factor contributing to the rising prevalence of heart failure in aging populations, as structural and functional changes occurring in the heart and vasculature during aging result in an increased susceptibility to heart failure. Different aging-related molecular mechanisms contribute to these cardiovascular changes. Among these molecular mechanisms are ep...

  REVIEW | Published: 29 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 9-18   PDF(1450KB)   Views：55Downloads：1

• Mid-life: a critical window for intervention during aging

  Evandro Lopes de Carvalho

  Mid-life represents a pivotal period marked by profound physiological and metabolic transitions, increasing susceptibility to chronic diseases. This review explores the molecular and systemic underpinnings of mid-life transition by integrating insights from recent studies that elucidate aging-associated changes in the plasma proteome, immune system, adipose tissue remodeling, and cellular senescen...

  REVIEW | Published: 14 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 1-8   PDF(1340KB)   Views：107Downloads：5

• CRISPR/Cas9 potential applications in cancer immunotherapy by gene-editing and immune checkpoint signaling pathway inhibition

  Mehab Ishfaq

  The mechanisms that drive immune feedback about cancer have been thoroughly explored over the years, particularly with a focus on utilizing the therapeutic potential of the immune system. Cancer immunotherapy has emerged as a promising treatment strategy for various types of cancer. Methods such as CAR T-cell therapy, adoptive T-cell therapy, monoclonal antibodies (mAbs), and cancer vaccines have ...

  REVIEW | Published: 31 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 94-102   PDF(1670KB)   Views：119Downloads：2

• TWIST1/miR-199a axis promotes tumor aggressiveness through inhibiting oxidative phosphorylation in carcinomas

  Umar Raza, Debmalya Roy

  Background Metabolic reprogramming has emerged as a key hallmark of cancer progression, though its role in tumor aggressiveness is still evolving. Here, using a pan-cancer genome approach, we aimed to comprehensively assess the metabolic reprogramming involved in tumor aggressiveness in carcinomas and identify metabolic hubs which can be therapeutically targeted to treat aggressive tumors in the c...

  RESEARCH | Published: 08 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 81-93   PDF(668KB)   Views：197Downloads：1

• Research advances in gut microbes and autism spectrum disorders

  Renardo Lico

  This paper concludes that recent research on the interrelationship between gut microbiota and autism spectrum disorder (ASD) has gained significant attention. The study found that the composition of the gut microbiota in ASD patients is often markedly different from that of the general population, particularly in the species and abundance of beneficial bacteria, such as Bifidobacterium and Lactoba...

  REVIEW | Published: 08 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 71-80   PDF(2000KB)   Views：148Downloads：3