Table of Contents

• Molecular basis of senescence in osteoarthritis

  Maria G. Lawson, Heather M. Ritchison

  Osteoarthritis (OA) is a multifaceted degenerative joint disorder with substantial global socioeconomic implications. Cellular senescence, defined by permanent cell cycle arrest, has been identified as a critical contributor to OA progression, driving the disruption of cartilage homeostasis and structural integrity. Here, we first delve into the molecular triggers of senescence in OA, including im...

  REVIEW | Published: 26 Nov 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 57-70   PDF(1770KB)   Views：197Downloads：4

• Role of PD-1/PD-L1 crosstalk on inhibition of T-cell activation and proliferation through blockade of PI3K/Akt/mTOR signaling pathway

  Jacob Smith

  Activation, differentiation, and proliferation of T-cells are the major parts of critical defense mechanisms that strengthen immune surveillance. Many crucial underlying mechanisms that act on the initiation of T-cell activation, survival, and proliferation. PI3K/Akt/mTOR signaling pathway is one of the key mechanisms that potentially acts on T-cell activation and growth through numerous pathways....

  REVIEW | Published: 21 Nov 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 49-56   PDF(1350KB)   Views：165Downloads：2

• Research progress of stem cell therapy for neurological diseases

  Muhammad Usman Taj, Muhammad Asim

  Neurological diseases are considered one of the leading causes of death and disability worldwide; not only do patients suffer, but they also place a significant economic burden on families and society. Traditional medications now show limited efficacy, and surgical interventions can be dangerous. The need to develop new medicines is critical as more people become aware of the immense burden this d...

  REVIEW | Published: 17 Sep 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 36-48   PDF(1860KB)   Views：278Downloads：1

• Cervicovaginal foetal fibronectin in predicting success of induced labour among nulliparous women: a systematic review

  Fawad Inayat, Imad Tariq ... Hadiqa Aimen

  The global rates of labor induction continue to exhibit a surge, attributed to a range of medical, obstetric, and non-medical factors. Although the Bishop score is often used to assess cervical preparation, its ability to accurately predict outcomes, particularly in nulliparous women with an unfavorable cervix, is still unknown. ...

  RESEARCH | Published: 02 Aug 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 28-35   PDF(709KB)   Views：432Downloads：5

• The relationship between vitamin D, chronic kidney disease, and mineral and bone disorder: a complex interplay comprehensive review

  Abdul Ghaffar, Ghulam Mustafa, Abdul Wahid

  Chronic kidney disease (CKD) is a global health concern with a significant prevalence. One major complication of CKD is mineral and bone disorder (MBD), characterized by abnormalities in calcium, phosphate, and parathyroid hormone (PTH) levels, leading to bone mineral density loss and increased fracture risk. Vitamin D deficiency is highly prevalent in CKD patients due to impaired kidney function ...

  REVIEW | Published: 09 Jun 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 22-27   PDF(810KB)   Views：440Downloads：10

• Prevalence and risk factors associated with neck pain among smartphone users at the University of Balochistan, Pakistan: a cross-sectional study

  Amna Bibi, Syed Anayat Ullah ... Abdul Wahid

  Shoulder and neck pain is a highly prevalent musculoskeletal disorder. Different factors have been associated with it; among these factors some common are the use of a computer and smartphones without a break, sitting in an uncomfortable position. It has been reported that the prevalence of neck pain among smartphone users ranges from 20.0%-73%. This study will evaluate the prevalence of neck pain...

  RESEARCH | Published: 18 May 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 13-21   PDF(718KB)   Views：474Downloads：5