Table of Contents

• TWIST1/miR-199a axis promotes tumor aggressiveness through inhibiting oxidative phosphorylation in carcinomas

  Umar Raza, Debmalya Roy

  Background Metabolic reprogramming has emerged as a key hallmark of cancer progression, though its role in tumor aggressiveness is still evolving. Here, using a pan-cancer genome approach, we aimed to comprehensively assess the metabolic reprogramming involved in tumor aggressiveness in carcinomas and identify metabolic hubs which can be therapeutically targeted to treat aggressive tumors in the c...

  RESEARCH | Published: 08 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 81-93   PDF(668KB)   Views：232Downloads：1

• Research advances in gut microbes and autism spectrum disorders

  Renardo Lico

  This paper concludes that recent research on the interrelationship between gut microbiota and autism spectrum disorder (ASD) has gained significant attention. The study found that the composition of the gut microbiota in ASD patients is often markedly different from that of the general population, particularly in the species and abundance of beneficial bacteria, such as Bifidobacterium and Lactoba...

  REVIEW | Published: 08 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 71-80   PDF(2000KB)   Views：177Downloads：4

• Molecular basis of senescence in osteoarthritis

  Maria G. Lawson, Heather M. Ritchison

  Osteoarthritis (OA) is a multifaceted degenerative joint disorder with substantial global socioeconomic implications. Cellular senescence, defined by permanent cell cycle arrest, has been identified as a critical contributor to OA progression, driving the disruption of cartilage homeostasis and structural integrity. Here, we first delve into the molecular triggers of senescence in OA, including im...

  REVIEW | Published: 26 Nov 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 57-70   PDF(1770KB)   Views：245Downloads：4

• Role of PD-1/PD-L1 crosstalk on inhibition of T-cell activation and proliferation through blockade of PI3K/Akt/mTOR signaling pathway

  Jacob Smith

  Activation, differentiation, and proliferation of T-cells are the major parts of critical defense mechanisms that strengthen immune surveillance. Many crucial underlying mechanisms that act on the initiation of T-cell activation, survival, and proliferation. PI3K/Akt/mTOR signaling pathway is one of the key mechanisms that potentially acts on T-cell activation and growth through numerous pathways....

  REVIEW | Published: 21 Nov 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 49-56   PDF(1350KB)   Views：198Downloads：2

• Research progress of stem cell therapy for neurological diseases

  Muhammad Usman Taj, Muhammad Asim

  Neurological diseases are considered one of the leading causes of death and disability worldwide; not only do patients suffer, but they also place a significant economic burden on families and society. Traditional medications now show limited efficacy, and surgical interventions can be dangerous. The need to develop new medicines is critical as more people become aware of the immense burden this d...

  REVIEW | Published: 17 Sep 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 36-48   PDF(1860KB)   Views：309Downloads：2

• Cervicovaginal foetal fibronectin in predicting success of induced labour among nulliparous women: a systematic review

  Fawad Inayat, Imad Tariq ... Hadiqa Aimen

  The global rates of labor induction continue to exhibit a surge, attributed to a range of medical, obstetric, and non-medical factors. Although the Bishop score is often used to assess cervical preparation, its ability to accurately predict outcomes, particularly in nulliparous women with an unfavorable cervix, is still unknown. ...

  RESEARCH | Published: 02 Aug 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 28-35   PDF(709KB)   Views：456Downloads：5