Table of Contents

• Aging-related comorbidities, life-style interventions and therapeutic strategies in heart failure

  Nam Nhut Phan, Fakhar-un-Nisa Yunus

  Aging is a key risk factor for heart failure which significantly contributes to progressive structural and functional deteriorations in the heart, such as increased incidence of left ventricular hypertrophy, decline in left ventricle diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac amyloidosis, all contributing to compromised cardiac performance and le...

  REVIEW | Published: 30 Mar 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 38-47   PDF(1670KB)   Views：30Downloads：1

• The role of adipose tissue aging in organismal aging

  Al Maskari Raya, Nomier Yousra

  Aging, a complex process marked by the progressive decline in cellular and systemic functions, increases vulnerability to metabolic and age-associated disorders. Adipose tissue, being the largest energy reservoir in the body, plays a crucial role in regulating metabolism and maintaining energy balance. Adipose tissue exhibit early onset of age-associated dysfunctions, which ultimately contribute t...

  REVIEW | Published: 23 Feb 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 28-37   PDF(2470KB)   Views：68Downloads：2

• Retraction: [Molecular bases of adipose tissue aging]

  Aakeel Ahmad, Manlio Fusciello

  Aging impacts each and every living organism. In higher organisms, it is an asynchronous process with its onset and pace varying among tissue types as well as among different cell types within a tissue. Adipose tissue is the largest energy depot in the body and is an endocrine organ responsible for metabolic homeostasis. Adipose tissue aging is marked by fat redistribution, with increased visceral...

  REVIEW | Published: 14 Feb 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 19-27   PDF(1740KB)   Views：116Downloads：8

• The role of cardiovascular aging in heart failure

  Denise Greco, Kofi Oti Boakye-Yiadom

  Cardiovascular aging represents a critical factor contributing to the rising prevalence of heart failure in aging populations, as structural and functional changes occurring in the heart and vasculature during aging result in an increased susceptibility to heart failure. Different aging-related molecular mechanisms contribute to these cardiovascular changes. Among these molecular mechanisms are ep...

  REVIEW | Published: 29 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 9-18   PDF(1450KB)   Views：99Downloads：1

• Mid-life: a critical window for intervention during aging

  Evandro Lopes de Carvalho

  Mid-life represents a pivotal period marked by profound physiological and metabolic transitions, increasing susceptibility to chronic diseases. This review explores the molecular and systemic underpinnings of mid-life transition by integrating insights from recent studies that elucidate aging-associated changes in the plasma proteome, immune system, adipose tissue remodeling, and cellular senescen...

  REVIEW | Published: 14 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Online First

  Pages: 1-8   PDF(1340KB)   Views：167Downloads：5

• CRISPR/Cas9 potential applications in cancer immunotherapy by gene-editing and immune checkpoint signaling pathway inhibition

  Mehab Ishfaq

  The mechanisms that drive immune feedback about cancer have been thoroughly explored over the years, particularly with a focus on utilizing the therapeutic potential of the immune system. Cancer immunotherapy has emerged as a promising treatment strategy for various types of cancer. Methods such as CAR T-cell therapy, adoptive T-cell therapy, monoclonal antibodies (mAbs), and cancer vaccines have ...

  REVIEW | Published: 31 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, Articles, Volume 1

  Pages: 94-102   PDF(1670KB)   Views：174Downloads：2