Table of Contents

• Mid-life: a critical window for intervention during aging

  Evandro Lopes de Carvalho

  Mid-life represents a pivotal period marked by profound physiological and metabolic transitions, increasing susceptibility to chronic diseases. This review explores the molecular and systemic underpinnings of mid-life transition by integrating insights from recent studies that elucidate aging-associated changes in the plasma proteome, immune system, adipose tissue remodeling, and cellular senescen...

  REVIEW | Published: 14 Jan 2025

  Asia-Pacific Journal of Surgical & Experimental Pathology, All Articles, Online First

  Pages: 1-8   PDF(1340KB)   Views：45Downloads：1

• CRISPR/Cas9 potential applications in cancer immunotherapy by gene-editing and immune checkpoint signaling pathway inhibition

  Mehab Ishfaq

  The mechanisms that drive immune feedback about cancer have been thoroughly explored over the years, particularly with a focus on utilizing the therapeutic potential of the immune system. Cancer immunotherapy has emerged as a promising treatment strategy for various types of cancer. Methods such as CAR T-cell therapy, adoptive T-cell therapy, monoclonal antibodies (mAbs), and cancer vaccines have ...

  REVIEW | Published: 31 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, All Articles, Volume 1

  Pages: 94-102   PDF(1670KB)   Views：64Downloads：2

• TWIST1/miR-199a axis promotes tumor aggressiveness through inhibiting oxidative phosphorylation in carcinomas

  Umar Raza, Debmalya Roy

  Background Metabolic reprogramming has emerged as a key hallmark of cancer progression, though its role in tumor aggressiveness is still evolving. Here, using a pan-cancer genome approach, we aimed to comprehensively assess the metabolic reprogramming involved in tumor aggressiveness in carcinomas and identify metabolic hubs which can be therapeutically targeted to treat aggressive tumors in the c...

  RESEARCH | Published: 08 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, All Articles, Volume 1

  Pages: 81-93   PDF(668KB)   Views：162Downloads：1

• Research advances in gut microbes and autism spectrum disorders

  Renardo Lico

  This paper concludes that recent research on the interrelationship between gut microbiota and autism spectrum disorder (ASD) has gained significant attention. The study found that the composition of the gut microbiota in ASD patients is often markedly different from that of the general population, particularly in the species and abundance of beneficial bacteria, such as Bifidobacterium and Lactoba...

  REVIEW | Published: 08 Dec 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, All Articles, Volume 1

  Pages: 71-80   PDF(2000KB)   Views：124Downloads：3

• Molecular basis of senescence in osteoarthritis

  Maria G. Lawson, Heather M. Ritchison

  Osteoarthritis (OA) is a multifaceted degenerative joint disorder with substantial global socioeconomic implications. Cellular senescence, defined by permanent cell cycle arrest, has been identified as a critical contributor to OA progression, driving the disruption of cartilage homeostasis and structural integrity. Here, we first delve into the molecular triggers of senescence in OA, including im...

  REVIEW | Published: 26 Nov 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, All Articles, Volume 1

  Pages: 57-70   PDF(1770KB)   Views：161Downloads：3

• Role of PD-1/PD-L1 crosstalk on inhibition of T-cell activation and proliferation through blockade of PI3K/Akt/mTOR signaling pathway

  Jacob Smith

  Activation, differentiation, and proliferation of T-cells are the major parts of critical defense mechanisms that strengthen immune surveillance. Many crucial underlying mechanisms that act on the initiation of T-cell activation, survival, and proliferation. PI3K/Akt/mTOR signaling pathway is one of the key mechanisms that potentially acts on T-cell activation and growth through numerous pathways....

  REVIEW | Published: 21 Nov 2024

  Asia-Pacific Journal of Surgical & Experimental Pathology, All Articles, Volume 1

  Pages: 49-56   PDF(1350KB)   Views：141Downloads：2